Abstract
In eukaryotic cells, the 3' poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3' end poly(A) tails in the nuclear surveillance and turnover of noncoding RNAs and intergenic mRNAs of unknown function.
MeSH terms
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Eukaryotic Cells / physiology*
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Models, Genetic*
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Multiprotein Complexes / metabolism
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Nucleotidyltransferases / metabolism*
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RNA 3' Polyadenylation Signals / genetics
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RNA 3' Polyadenylation Signals / physiology*
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RNA Processing, Post-Transcriptional / genetics
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RNA Processing, Post-Transcriptional / physiology*
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RNA Stability / genetics
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RNA Stability / physiology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
Substances
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Multiprotein Complexes
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RNA, Messenger
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Nucleotidyltransferases