RNA turnover: unexpected consequences of being tailed

Curr Biol. 2005 Aug 23;15(16):R635-8. doi: 10.1016/j.cub.2005.08.002.

Abstract

In eukaryotic cells, the 3' poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3' end poly(A) tails in the nuclear surveillance and turnover of noncoding RNAs and intergenic mRNAs of unknown function.

Publication types

  • Review

MeSH terms

  • Eukaryotic Cells / physiology*
  • Models, Genetic*
  • Multiprotein Complexes / metabolism
  • Nucleotidyltransferases / metabolism*
  • RNA 3' Polyadenylation Signals / genetics
  • RNA 3' Polyadenylation Signals / physiology*
  • RNA Processing, Post-Transcriptional / genetics
  • RNA Processing, Post-Transcriptional / physiology*
  • RNA Stability / genetics
  • RNA Stability / physiology*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*

Substances

  • Multiprotein Complexes
  • RNA, Messenger
  • Nucleotidyltransferases