[Molecular and genetic characterization of rifampicin- and/or izoniazid-resistent strains of M. tuberculosis, isolated in Novosibirsk and Tomsk regions]

S I Tat'kov; O V Norkina; M L Filipenko; A Iu Sivkov; A N Boldyrev; M Sh Azaev; V N Kinsht; Iu N Kurunov; V A Krasnov; E V Medvedeva; O I Baranova; A P Ivlev-Duntau; S A Bodnev; L N Blinova; A D Pasechnikov

[Molecular and genetic characterization of rifampicin- and/or izoniazid-resistent strains of M. tuberculosis, isolated in Novosibirsk and Tomsk regions]

Vestn Ross Akad Med Nauk. 2005:(7):26-36.

[Article in Russian]

Authors

S I Tat'kov, O V Norkina, M L Filipenko, A Iu Sivkov, A N Boldyrev, M Sh Azaev, V N Kinsht, Iu N Kurunov, V A Krasnov, E V Medvedeva, O I Baranova, A P Ivlev-Duntau, S A Bodnev, L N Blinova, A D Pasechnikov

PMID: 16107019

Abstract

The purpose of the work was to study rifampicin- and izoniazid-resistent strains of M. tuberculosis, circulating in Western Siberia, by VNTR and IS6110 typing. The authors also studied genetic causes of resistance to these antibiotics and undertook a search of new VNTR loci, displaying polymorphism in genomes of closely related clonally-disseminated variants of Mycobacterium tuberculosis in W-Beijing family model analysis.

Publication types

Comparative Study
English Abstract

MeSH terms

Antitubercular Agents / pharmacology*
Drug Resistance, Bacterial / genetics*
Genome, Bacterial
Humans
Isoniazid / pharmacology*
Minisatellite Repeats / genetics
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / isolation & purification
Mycobacterium tuberculosis / metabolism*
Polymorphism, Genetic
Retrospective Studies
Rifamycins / pharmacology*
Siberia / epidemiology
Tuberculosis / drug therapy
Tuberculosis / epidemiology
Tuberculosis / microbiology

Substances

Antitubercular Agents
Rifamycins
Isoniazid