Innovative, multifunctional sequential oligopeptide carriers Soc(n)-I and SOC(n)-II: functions-technology-perspectives

Protein Pept Lett. 2005 Aug;12(6):601-7. doi: 10.2174/0929866054395914.

Abstract

An innovative type of multifunctional helicoid artificial carriers, formed by the repetitive Lys-Aib-Gly (SOC(n)-I) or by the Aib-Lys-Aib-Gly (SOC(n)-II), with structural rigidity and regularity were successfully applied in our laboratory for anchoring antigenic/immunogenic peptides. The carriers, designed to display a predetermined 3D structure, adopt the 3(10) helical conformation, while the attached peptides preserve their original "active" conformation. The constructed conjugates were used as substrates in solid phase immunoassays, as well as for generating potent and specific immune responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Autoantibodies / immunology
  • Biological Transport
  • Humans
  • Immunoconjugates / chemistry*
  • Immunoconjugates / immunology*
  • Immunoconjugates / isolation & purification
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / immunology
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Oligopeptides / immunology*
  • Oligopeptides / isolation & purification

Substances

  • Autoantibodies
  • Immunoconjugates
  • Oligopeptides
  • Metalloendopeptidases
  • glycoprotein gp63, Leishmania