Abstract
In this review we present data concerning the localization of some important growth factors and their receptors in the human placenta. We focus our attention on molecules playing a fundamental role in angiogenesis and morphologic processes as beta-FGF, EGF and TGF-beta. The distribution of these growth factors and their receptors in the placental villi during gestation suggests that these molecules play a pivotal role in growth and differentiation of the villous tree.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Chorionic Villi / blood supply
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Chorionic Villi / metabolism
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Chorionic Villi / ultrastructure
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Female
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Growth Substances / metabolism*
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Humans
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Microcirculation / growth & development
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Microcirculation / ultrastructure
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Neovascularization, Physiologic / physiology
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Placenta / blood supply
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Placenta / metabolism*
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Placental Circulation / physiology
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Placentation* / physiology*
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Pregnancy
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Receptors, Growth Factor / metabolism*
Substances
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Growth Substances
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Receptors, Growth Factor