Abstract
The 3-hydroxy-4-pyridinones are chelating agents of current interest due to their high affinity for hard metal ions and potential clinical applications as metal-decorporation agents. A new bis-(3-hydroxy-4-pyridinone) derivative of EDTA have been developed, and herein we describe the results of solution studies to determine the protonation constants and the partition coefficient. Biodistribution studies, performed with 67Ga-overload mice, showed rapid clearance of the radiotracer from the body, thus indicating that the new ligand should be a quite effective agent for the in vivo aluminium removal.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aluminum / chemistry*
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Animals
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Chelating Agents / chemical synthesis*
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Chelating Agents / chemistry
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Chelating Agents / pharmacokinetics
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Chelating Agents / pharmacology*
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Edetic Acid / analogs & derivatives*
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Edetic Acid / chemical synthesis
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Edetic Acid / chemistry
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Edetic Acid / pharmacokinetics
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Edetic Acid / pharmacology
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Female
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Magnetic Resonance Spectroscopy
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Mice
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Solutions
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Tissue Distribution
Substances
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Chelating Agents
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Solutions
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ethylenodiamino-N,N'-bis(acetocarboxyl)-N,N'-bis(acetyl(1-(3'-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone))
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Edetic Acid
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Aluminum