Palladium-catalyzed one-pot synthesis of highly substituted furans by a three-component annulation reaction

J Org Chem. 2005 Aug 19;70(17):6980-3. doi: 10.1021/jo050908d.

Abstract

A new three-component cyclization-coupling reaction catalyzed by palladium was developed, producing polysubstituted furans in good yields from readily available substrates. The reaction conditions and the scope of the process were examined, and a possible mechanism is proposed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Catalysis
  • Furans / chemical synthesis*
  • Magnetic Resonance Spectroscopy
  • Palladium / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared

Substances

  • Furans
  • Palladium