Development of multifunctional polymer-mineral composite materials for bone tissue engineering

J Biomed Mater Res A. 2005 Nov 1;75(2):333-41. doi: 10.1002/jbm.a.30428.

Abstract

The main goal of this article is the development of a novel approach to construct multifunctional composite scaffolds for bone tissue engineering. For this purpose, different kinds of mineral macroporous supports, water-soluble aldehyde-containing copolymers of N-vinylpyrrolidone, as well as different nonspecific and biospecific ligands governing cell adhesion and growth have been used. The composite materials were tested initially for cytotoxicity in cell culture experiments using a model cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Bone Substitutes / chemistry*
  • Bone Substitutes / metabolism
  • Bone and Bones* / cytology
  • Bone and Bones* / physiology
  • Cell Line
  • Coated Materials, Biocompatible / chemistry*
  • Coated Materials, Biocompatible / metabolism
  • Humans
  • Lysine / chemistry
  • Minerals / chemistry*
  • Molecular Structure
  • Polymers / chemistry*
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / metabolism
  • Tissue Engineering / methods*

Substances

  • Bone Substitutes
  • Coated Materials, Biocompatible
  • Minerals
  • Polymers
  • Pyrrolidinones
  • N-vinyl-2-pyrrolidinone
  • Lysine