Phenotypic and genotypic mupirocin resistance among Staphylococci causing prosthetic joint infection

J Clin Microbiol. 2005 Aug;43(8):4266-8. doi: 10.1128/JCM.43.8.4266-4268.2005.

Abstract

Mupirocin MICs and mupA presence were determined in 108 staphylococci causing prosthetic joint infection. Zero of 35 isolates (0%) of methicillin-susceptible Staphylococcus aureus, 4/15 (27%) methicillin-resistant S. aureus isolates, 3/16 (19%) methicillin-susceptible coagulase-negative staphylococci, and 11/42 (26%) methicillin-resistant coagulase-negative staphylococci were mupirocin resistant. mupA was detected in all five high-level mupirocin-resistant staphylococci and one mupirocin-susceptible staphylococcus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial
  • Female
  • Genotype
  • Humans
  • Joint Prosthesis / adverse effects*
  • Male
  • Methicillin Resistance
  • Middle Aged
  • Mupirocin / pharmacology*
  • Phenotype
  • Staphylococcal Infections / microbiology*
  • Staphylococcus / classification
  • Staphylococcus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Mupirocin