Objective: To study the expression of ICAM-1 in laryngeal carcinoma and it's significance.
Method: ICAM-1 were detected in 78 cases laryngeal carcinoma, 30 cases dysplasia and 5 cases normal by SP immunohistochemistry.
Result: ICAM-1 can be expressed on the lymphocytes of patients with laryngeal carcinoma, but not cells of normal, dysplasia and cancer. The first and second stages laryngeal carcinoma had stronger ICAM-1 expression than those of the third and fourth stages (P < 0.05). ICAM-1 expression in laryngeal carcinoma with cervical metastasis was higher than that without cervical metastasis (P < 0.05). Three and five years survival rate in patients with higher ICAM-1 expression were higher than those of patients with lower ICAM-1 expression (P < 0.05).
Conclusion: These results implicate that the development, metastasis and prognosis of laryngeal carcinoma may be correlated to ICAM-1 expression of lymphocyte.