Self injurious behavior in autism: clinical aspects and treatment with risperidone

J Neural Transm (Vienna). 2006 Mar;113(3):425-31. doi: 10.1007/s00702-005-0337-x. Epub 2005 Aug 3.

Abstract

Self injurious behavior (SIB) is frequent in autistic spectrum disorders. The aim of this study was to investigate the phenomenology of SIB in a group of children with autistic disorder, and to test whether treatment with risperidone might reduce it. A group of eleven children diagnosed with autistic disorder according to the DSM-IV criteria (mean age 8.7+/-2.2 ys) and with severe SIB were recruited for an open study of six months of treatment with risperidone. The Yale-Paris Self-Injurious Behavior Scale was used to delineate the clinical characteristics and as an outcome measure. Head-hitting and hand biting were the most frequent forms of self aggression observed. Nine children presented a mild improvement in SIB and 2 did not show any variation. A decrease in Yale-Paris Self Injurious Behavior Scale score (from M 15.1+/-1.4 to 13.3+/-1.4) was noted mainly due to the reduction of frequency. Side effects of risperidone were not severe.

Publication types

  • Clinical Trial

MeSH terms

  • Antipsychotic Agents / administration & dosage*
  • Antipsychotic Agents / adverse effects
  • Autistic Disorder / complications*
  • Autistic Disorder / drug therapy*
  • Autistic Disorder / physiopathology
  • Brain / drug effects
  • Brain / metabolism
  • Brain / physiopathology
  • Brain Chemistry / drug effects
  • Brain Chemistry / physiology
  • Child
  • Dopamine / metabolism
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / metabolism
  • Risperidone / administration & dosage*
  • Risperidone / adverse effects
  • Self-Injurious Behavior / drug therapy*
  • Self-Injurious Behavior / etiology*
  • Self-Injurious Behavior / physiopathology
  • Serotonin / metabolism
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • Treatment Outcome
  • Weight Gain / drug effects

Substances

  • Antipsychotic Agents
  • Receptors, Dopamine
  • Receptors, Serotonin
  • Serotonin
  • Risperidone
  • Dopamine