Spontaneous fractures in a patient treated with low doses of etidronic acid (disodium etidronate)

Drug Saf. 1992 Mar-Apr;7(2):162-5. doi: 10.2165/00002018-199207020-00008.

Abstract

The recommended regimen of etidronic acid (disodium etidronate) for the treatment of Paget's disease of bone is 5mg/kg/day for a period of less than six months. There have, however, been reports of impaired mineralisation of bone and concern that the risk of fracture is increased with this dosage. We report a patient with Paget's disease in whom fractures occurred through pagetic and non-pagetic bone which appeared to be causally related to treatment with lose doses of etidronic acid. The osteomalacia resolved when etidronic acid was discontinued.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Etidronic Acid / administration & dosage
  • Etidronic Acid / adverse effects*
  • Female
  • Femoral Neck Fractures / etiology
  • Fractures, Spontaneous / etiology*
  • Humans
  • Osteitis Deformans / drug therapy*
  • Osteomalacia / chemically induced
  • Osteomalacia / complications
  • Tibial Fractures / etiology

Substances

  • Etidronic Acid