In vitro efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus

Antimicrob Agents Chemother. 2005 Aug;49(8):3489-91. doi: 10.1128/AAC.49.8.3489-3491.2005.

Abstract

We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V. vulnificus in vitro, and this combination regimen can be a good choice as the empirical treatment for suspected necrotizing fasciitis due to V. vulnificus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Anti-Infective Agents / standards
  • Cefotaxime / pharmacology*
  • Ciprofloxacin / pharmacology*
  • Colony Count, Microbial
  • Drug Synergism
  • Humans
  • Microbial Sensitivity Tests / methods
  • Minocycline / pharmacology
  • Vibrio vulnificus / drug effects*
  • Vibrio vulnificus / growth & development

Substances

  • Anti-Infective Agents
  • Ciprofloxacin
  • Minocycline
  • Cefotaxime