Synthesis of 1-(N-ethoxycarbonylamino)alkylphosphonic monoesters

H Liu; J X Xu

doi:10.1007/s00726-005-0224-7

Synthesis of 1-(N-ethoxycarbonylamino)alkylphosphonic monoesters

Amino Acids. 2005 Nov;29(3):241-3. doi: 10.1007/s00726-005-0224-7. Epub 2005 Jul 28.

Authors

H Liu¹, J X Xu

Affiliation

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

PMID: 16044194
DOI: 10.1007/s00726-005-0224-7

Abstract

A series of 1-(N-ethoxycarbonylamino)alkylphosphonic monoesters were synthesized via three-component Mannich-type condensation of ethyl carbamate, aldehydes and dichlorophosphites in benzene, followed by hydrolysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Hydrolysis
Magnetic Resonance Spectroscopy / methods
Magnetic Resonance Spectroscopy / standards
Molecular Structure
Organophosphonates / chemical synthesis*
Organophosphonates / chemistry
Phosphites / chemistry*
Reference Standards
Urethane / chemistry*

Substances

Aldehydes
Organophosphonates
Phosphites
Urethane