CNS regeneration: a morphogen's tale

J Neurobiol. 2005 Sep 15;64(4):491-507. doi: 10.1002/neu.20158.

Abstract

Tissue regeneration will soon become an avenue for repair of damaged or diseased tissues as stem cell niches have been found in almost every organ of the vertebrate body including the CNS. In addition, different animals display an array of regenerative capabilities that are currently being researched to dissect the molecular mechanisms involved. This review concentrates on the different ways in which CNS tissues such as brain, spinal cord and retina can regenerate or display neurogenic potential and how these abilities are modulated by morphogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / physiology
  • Central Nervous System / physiology*
  • Growth Substances / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins / physiology*
  • Nerve Regeneration / physiology*
  • Signal Transduction / physiology
  • Tretinoin / physiology

Substances

  • Bone Morphogenetic Proteins
  • Growth Substances
  • Intracellular Signaling Peptides and Proteins
  • Tretinoin