Abstract
Herein, we identify vceC as a component of a vceCAB operon, which codes for the Vibrio cholerae VceAB multiple-drug resistance (MDR) efflux pump, and vceR, which codes for a transcriptional autoregulatory protein that negatively regulates the expression of the vceCAB operon and is modulated by some of the substrates of this MDR efflux pump.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis
-
ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
-
Bacterial Outer Membrane Proteins / biosynthesis
-
Bacterial Outer Membrane Proteins / genetics*
-
Bacterial Proteins / genetics
-
Binding Sites
-
Drug Resistance, Multiple, Bacterial / genetics
-
Escherichia coli / genetics
-
Escherichia coli / metabolism
-
Genes, Regulator*
-
Ion Pumps / genetics
-
Membrane Proteins / genetics
-
Mutagenesis, Insertional
-
Open Reading Frames
-
Operon*
-
Reverse Transcriptase Polymerase Chain Reaction
-
Vibrio cholerae / genetics*
Substances
-
ATP Binding Cassette Transporter, Subfamily B, Member 1
-
Bacterial Outer Membrane Proteins
-
Bacterial Proteins
-
Ion Pumps
-
Membrane Proteins
-
VceA protein, Vibrio cholerae
-
VceC protein, Vibrio cholerae
-
VceB protein, Vibrio cholerae