Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095

Peptides. 2005 Dec;26(12):2525-9. doi: 10.1016/j.peptides.2005.06.006. Epub 2005 Jul 14.

Abstract

The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, Leu(13) psi(CH2NH)-Leu14] bombesin (6-14) (RC-3095) (0.2, 1.0 or 5.0mg/kg) 30 min before exposure to an open field or an elevated plus maze. Habituation to the open field was tested in a retention trial carried out 24 h after the first exposure to the open field. Rats given RC-3095 at the doses of 1.0 or 5.0mg/kg showed impaired habituation. Animals treated with 5.0mg/kg of RC-3095 spent significantly more time in the closed arms of the elevated plus maze. No effects of RC-3095 on locomotion or exploratory behavior were observed. The results implicate the GRPR in the regulation of non-emotional, non-associative memory as well as in anxiety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Anxiety*
  • Behavior, Animal / drug effects*
  • Bombesin / administration & dosage
  • Bombesin / analogs & derivatives*
  • Dose-Response Relationship, Drug
  • Injections, Intraperitoneal
  • Locomotion / drug effects
  • Male
  • Maze Learning / drug effects*
  • Memory / drug effects
  • Peptide Fragments / administration & dosage*
  • Rats
  • Rats, Wistar
  • Receptors, Bombesin / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Peptide Fragments
  • Receptors, Bombesin
  • bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-
  • Bombesin