Abstract
We demonstrate that a mixture of four recombinant dengue virus E polypeptides corresponding to the N-terminal region of the envelope protein from all serotypes substitutes for standard antigens in two immunoglobulin M enzyme-linked immunosorbent assay formats with 100% concordance, making these polypeptides a useful and accessible reagent for serological diagnosis of dengue in endemic countries.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibodies, Viral / immunology*
-
Capsid Proteins* / immunology
-
Dengue / diagnosis*
-
Dengue / immunology
-
Dengue Virus / genetics
-
Dengue Virus / immunology*
-
Enzyme-Linked Immunosorbent Assay / methods
-
Humans
-
Immunoglobulin M / immunology*
-
Recombinant Proteins / genetics
Substances
-
Antibodies, Viral
-
Capsid Proteins
-
Immunoglobulin M
-
Recombinant Proteins