Abstract
Using DNA subtractive hybridization, 49 unique gene segments were identified from a strain of Streptococcus mutans that was isolated from a patient with severe early childhood caries (S-ECC). Further hybridization with DNA from other S. mutans strains isolated from both caries-active and caries-free subjects yielded five unique sequences of DNA common to strains associated with S-ECC.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Child
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Child, Preschool
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DNA, Bacterial / analysis*
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DNA, Bacterial / genetics
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Dental Caries / microbiology*
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Dental Caries Susceptibility
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Genes, Bacterial*
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Humans
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Male
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Molecular Sequence Data
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Nucleic Acid Hybridization / methods*
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Polymerase Chain Reaction / methods*
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Sequence Analysis, DNA
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Streptococcus mutans / genetics*
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Streptococcus mutans / pathogenicity
Associated data
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GENBANK/DQ072007
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GENBANK/DQ072008