Feasibility of early tapering of cyclosporine following reduced-intensity stem cell transplantation for advanced hematologic or solid malignancies

Haematologica. 2005 Jul;90(7):1001-3.

Abstract

Although some researchers have reported that early tapering of cyclosporine is feasible and beneficial to augment graft-versus-leukemia effects after conventional stem-cell transplantation, there is little information on the feasibility of this strategy following reduced-intensity stem cell transplantation (RIST). We summarized outcomes of 17 patients who underwent early tapering of cyclosporine following RIST from HLA-identical siblings.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cyclosporine / administration & dosage*
  • Graft vs Host Disease
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Middle Aged
  • Neoplasms / therapy*
  • Retrospective Studies
  • Stem Cell Transplantation / methods*
  • Time Factors
  • Transplantation Conditioning
  • Transplantation, Homologous
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Cyclosporine