Abstract
We evaluated the role of D-amino-acid oxidase on spatial learning and long-term potentiation (LTP) in the hippocampus, since this enzyme metabolizes D-amino-acids, some of which enhance the N-methyl-D-aspartate receptor functions. The Morris water maze learning and the LTP in the CA1 area of the hippocampal slice were observed in wild-type mice and mutant mice lacking D-amino-acid oxidase. The mutant mice showed significantly shorter platform search times in the water maze and significantly larger hippocampal LTPs than the wild-type mice. These results suggest that the abundant D-amino-acids in the mutant mouse brain facilitate hippocampal LTP and spatial learning.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Analysis of Variance
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Animals
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Behavior, Animal / physiology
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D-Amino-Acid Oxidase / deficiency*
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Electric Stimulation / methods
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Excitatory Postsynaptic Potentials / radiation effects
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Hippocampus / drug effects
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Hippocampus / physiology*
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Hippocampus / radiation effects
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In Vitro Techniques
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Learning / drug effects
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Learning / physiology*
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Learning / radiation effects
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Long-Term Potentiation / drug effects
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Long-Term Potentiation / genetics*
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Long-Term Potentiation / radiation effects
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Male
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Maze Learning / physiology
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Membrane Potentials / drug effects
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Membrane Potentials / physiology
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Membrane Potentials / radiation effects
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Mice
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Mice, Knockout
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Patch-Clamp Techniques / methods
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Pyramidal Cells / drug effects
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Pyramidal Cells / radiation effects
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Spatial Behavior / drug effects
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Spatial Behavior / physiology*
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Spatial Behavior / radiation effects
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Swimming / physiology
Substances
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Excitatory Amino Acid Antagonists
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6-Cyano-7-nitroquinoxaline-2,3-dione
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D-Amino-Acid Oxidase