Development of a stepwise [3 + 3] annelation to functionalized piperidines

Katharine M Goodenough; Piotr Raubo; Joseph P A Harrity

doi:10.1021/ol050965t

Development of a stepwise [3 + 3] annelation to functionalized piperidines

Org Lett. 2005 Jul 7;7(14):2993-6. doi: 10.1021/ol050965t.

Authors

Katharine M Goodenough¹, Piotr Raubo, Joseph P A Harrity

Affiliation

¹ Department of Chemistry, University of Sheffield, Brook Hill, UK.

PMID: 15987188
DOI: 10.1021/ol050965t

Abstract

[reaction: see text] A stepwise formal [3 + 3] cycloaddition sequence via a Grignard addition-cyclization reaction leads to a much improved piperidine synthesis. This methodology provides improved flexibility in both the aziridine substrate and TMM equivalent.