Synthesis of multitopic neoglycopeptides displaying recognition and detection motifs

Olivier Renaudet; Pascal Dumy

doi:10.1016/j.bmcl.2005.05.072

Synthesis of multitopic neoglycopeptides displaying recognition and detection motifs

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3619-22. doi: 10.1016/j.bmcl.2005.05.072.

Authors

Olivier Renaudet¹, Pascal Dumy

Affiliation

¹ LEDSS, UMR-CNRS 5616 & ICMG FR 2607, Université Joseph Fourier, BP 53 38041 Grenoble Cedéx 9, France.

PMID: 15982871
DOI: 10.1016/j.bmcl.2005.05.072

Abstract

We describe herein the synthesis of cyclic decapeptide template displaying clustered carbohydrate recognition motifs and detection agent on spatially separated domains. Such multitopic labeled neoglycopeptides represent attractive tools for binding assays with carbohydrate binding proteins in glycomic research.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Motifs
Binding Sites
Carbohydrates / chemistry*
Chromatography, High Pressure Liquid
Glycopeptides / chemical synthesis*
Models, Chemical
Peptides, Cyclic / chemical synthesis*

Substances

Carbohydrates
Glycopeptides
Peptides, Cyclic