A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes

Simone Rochfort; Joanne Ford; Simon Ovenden; Soo San Wan; Samantha George; Howard Wildman; R Murray Tait; Barbara Meurer-Grimes; Susan Cox; Jonathan Coates; David Rhodes

doi:10.1038/ja.2005.34

A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes

J Antibiot (Tokyo). 2005 Apr;58(4):279-83. doi: 10.1038/ja.2005.34.

Authors

Simone Rochfort¹, Joanne Ford, Simon Ovenden, Soo San Wan, Samantha George, Howard Wildman, R Murray Tait, Barbara Meurer-Grimes, Susan Cox, Jonathan Coates, David Rhodes

Affiliation

¹ Cerylid Biosciences, 576 Swan Street, Richmond, Victoria 3121, Australia. simone.rochfort@dpi.vic.gov.au

PMID: 15981416
DOI: 10.1038/ja.2005.34

Abstract

A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspergillus / chemistry
Aspergillus / metabolism*
Chemical Phenomena
Chemistry, Physical
Culture Media
Cytochalasins / isolation & purification
Cytochalasins / pharmacology*
Fermentation
HIV Integrase Inhibitors / isolation & purification
HIV Integrase Inhibitors / pharmacology*
HIV-1 / drug effects
HIV-1 / enzymology*
Magnetic Resonance Spectroscopy
Molecular Conformation
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared

Substances

Culture Media
Cytochalasins
HIV Integrase Inhibitors
aspochalasin L