Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132

J Antibiot (Tokyo). 2005 Apr;58(4):252-9. doi: 10.1038/ja.2005.29.

Abstract

Two new phenols, designated phenatic acids A and B, were isolated along with known actiphenol, from the culture of Streptomyces sp. K03-0132 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analyses including mainly various NMR experiments. They have a common 1-hydroxy 2, 4-dimethyl benzene ring. These compounds potentiate miconazole activity against Candida albicans. Phenatic acid B also showed moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Bacteroides fragilis and Acholeplasma laidlawii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / metabolism*
  • Acetates / pharmacology*
  • Antifungal Agents / biosynthesis*
  • Antifungal Agents / pharmacology*
  • Bacteria / drug effects
  • Candida albicans / drug effects
  • Chemical Phenomena
  • Chemistry, Physical
  • Drug Synergism
  • Fermentation
  • Glutarates / metabolism*
  • Glutarates / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Miconazole / pharmacology*
  • Microbial Sensitivity Tests
  • Phenols / metabolism*
  • Phenols / pharmacology*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Streptomyces / classification
  • Streptomyces / metabolism*

Substances

  • Acetates
  • Antifungal Agents
  • Glutarates
  • Phenols
  • phenatic acid A
  • phenatic acid B
  • Miconazole