Abstract
Two new phenols, designated phenatic acids A and B, were isolated along with known actiphenol, from the culture of Streptomyces sp. K03-0132 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analyses including mainly various NMR experiments. They have a common 1-hydroxy 2, 4-dimethyl benzene ring. These compounds potentiate miconazole activity against Candida albicans. Phenatic acid B also showed moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Bacteroides fragilis and Acholeplasma laidlawii.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / metabolism*
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Acetates / pharmacology*
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Antifungal Agents / biosynthesis*
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Candida albicans / drug effects
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Chemical Phenomena
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Chemistry, Physical
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Drug Synergism
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Fermentation
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Glutarates / metabolism*
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Glutarates / pharmacology*
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Magnetic Resonance Spectroscopy
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Miconazole / pharmacology*
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Microbial Sensitivity Tests
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Phenols / metabolism*
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Phenols / pharmacology*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
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Streptomyces / classification
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Streptomyces / metabolism*
Substances
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Acetates
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Antifungal Agents
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Glutarates
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Phenols
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phenatic acid A
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phenatic acid B
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Miconazole