Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Giovanni Appendino; Gabriella Aviello; Mauro Ballero; Francesca Borrelli; Ernesto Fattorusso; Francesca Petrucci; Federico U Santelia; Orazio Taglialatela-Scafati

doi:10.1021/np050120q

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

J Nat Prod. 2005 Jun;68(6):853-7. doi: 10.1021/np050120q.

Authors

Giovanni Appendino¹, Gabriella Aviello, Mauro Ballero, Francesca Borrelli, Ernesto Fattorusso, Francesca Petrucci, Federico U Santelia, Orazio Taglialatela-Scafati

Affiliation

¹ Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Italy.

PMID: 15974607
DOI: 10.1021/np050120q

Abstract

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Asteraceae / chemistry*
Drug Screening Assays, Antitumor
Humans
Italy
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Sesquiterpenes, Germacrane / chemistry
Sesquiterpenes, Germacrane / isolation & purification*
Sesquiterpenes, Germacrane / pharmacology
Stereoisomerism

Substances

Antineoplastic Agents, Phytogenic
Sesquiterpenes, Germacrane