Enantioseparation of 1-phenyl-1-propanol on Chiralcel OD by supercritical fluid chromatography. I. Linear isotherm

Arvind Rajendran; Marco Mazzotti; Massimo Morbidelli

doi:10.1016/j.chroma.2005.04.023

Enantioseparation of 1-phenyl-1-propanol on Chiralcel OD by supercritical fluid chromatography. I. Linear isotherm

J Chromatogr A. 2005 May 27;1076(1-2):183-8. doi: 10.1016/j.chroma.2005.04.023.

Authors

Arvind Rajendran¹, Marco Mazzotti, Massimo Morbidelli

Affiliation

¹ ETH Swiss Federal Institute of Technology Zurich, Institute of Process Engineering, Sonneggstrasse 3, CH-8092 Zürich, Switzerland.

PMID: 15974086
DOI: 10.1016/j.chroma.2005.04.023

Abstract

The supercritical fluid chromatography (SFC) separation of the enantiomers of 1-phenyl-1-propanol on the chiral stationary phase Chiralcel OD under linear conditions is studied. Supercritical CO2 modified with methanol is used as a mobile phase. The effect of modifier concentration, pressure and temperature is studied. An empirical isotherm to account for the effect of density of the mobile phase and modifier concentration has been used to model the experimental results. It was observed that the selectivity and resolution were higher at 30 degrees C as compared to those at 40 degrees C.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Benzyl Alcohols / isolation & purification*
Chromatography, Supercritical Fluid / methods*
Stereoisomerism
Thermodynamics

Substances

Benzyl Alcohols
alpha-ethylbenzyl alcohol