Abstract
We have previously shown that phosphatidylinositol-specific phospholipase C (PI-PLC) produced by Listeria monocytogenes activates a host protein kinase C (PKC) cascade which promotes escape of the bacterium from a macrophage-like cell phagosome. Here, we provide evidence linking bacterial PI-PLC and host PKC beta to phagosome permeabilization, which precedes escape.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Bacterial Toxins
-
Heat-Shock Proteins / physiology
-
Hemolysin Proteins
-
Hydrogen-Ion Concentration
-
Indoles / pharmacology
-
Listeria monocytogenes / enzymology*
-
Macrophages / metabolism*
-
Maleimides / pharmacology
-
Mice
-
Permeability
-
Phagosomes / metabolism*
-
Phosphatidylinositol Diacylglycerol-Lyase / physiology*
-
Phosphoinositide Phospholipase C
-
Protein Kinase C / physiology*
Substances
-
Bacterial Toxins
-
Heat-Shock Proteins
-
Hemolysin Proteins
-
Indoles
-
Maleimides
-
Ro 31-8425
-
Protein Kinase C
-
Phosphoinositide Phospholipase C
-
Phosphatidylinositol Diacylglycerol-Lyase
-
hlyA protein, Listeria monocytogenes