Anti-HIV bioactive stilbene dimers of Caragana rosea

Planta Med. 2005 Jun;71(6):569-71. doi: 10.1055/s-2005-864162.

Abstract

Bioassay-guided fractionation of the ethanol extract of the aerial parts of Caragana rosea Turcz. led to the isolation of two new (cararosinol C and cararosinol D) and four known [scirpusin A (1), cis-scirpusin A (2), maackin (3), scirpusin B (4)] stilbene dimers. This is the first identification of these compounds from this plant and the first time that compound 2 has been isolated as a natural compound. Their structures were established mainly by spectral means. An in vitro assay against HIV-1 (IIIB), demonstrated compounds 1 and 4 to be active against HIV, with EC50 values of 10 microg/mL and 7 microg/mL respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / pharmacology*
  • Anti-HIV Agents / therapeutic use
  • Caragana*
  • HIV-1 / drug effects*
  • Humans
  • Inhibitory Concentration 50
  • Phytotherapy*
  • Plant Components, Aerial
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Stilbenes / administration & dosage
  • Stilbenes / pharmacology*
  • Stilbenes / therapeutic use

Substances

  • Anti-HIV Agents
  • Plant Extracts
  • Stilbenes