Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid

Alessandra Ammazzalorso; Rosa Amoroso; Mario Baraldi; Giancarlo Bettoni; Daniela Braghiroli; Barbara De Filippis; Letizia Giampietro; Maria L Tricca; Francesca Vezzalini

doi:10.1016/j.ejmech.2005.03.022

Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid

Eur J Med Chem. 2005 Sep;40(9):918-21. doi: 10.1016/j.ejmech.2005.03.022. Epub 2005 Jun 13.

Authors

Alessandra Ammazzalorso¹, Rosa Amoroso, Mario Baraldi, Giancarlo Bettoni, Daniela Braghiroli, Barbara De Filippis, Letizia Giampietro, Maria L Tricca, Francesca Vezzalini

Affiliation

¹ Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, via dei Vestini, 66100 Chieti, Italy.

PMID: 15950326
DOI: 10.1016/j.ejmech.2005.03.022

Abstract

The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 analyzer using bull blood.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Clofibric Acid / analogs & derivatives
Clofibric Acid / chemical synthesis*
Clofibric Acid / pharmacology*
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Hypolipidemic Agents / chemical synthesis
Hypolipidemic Agents / chemistry
Hypolipidemic Agents / pharmacology
Platelet Aggregation / drug effects*
Thiazoles / chemical synthesis
Thiazoles / pharmacology*

Substances

Hypolipidemic Agents
Thiazoles
Clofibric Acid