Antitrypanosomal activity of a novel norlignan purified from Nectandra lineata

Nat Prod Res. 2005 Jun;19(4):373-7. doi: 10.1080/1478641042000261950.

Abstract

Bioactivity-guided fractionation of a MeOH-EtOAc extract from the young leaves of Nectandra lineata (Lauraceae), using a Trypanosoma cruzi bioassay resulted in the isolation of a novel norlignan 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy (1), together with the known compound, 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene (2). Compounds 1 and 2 were shown to inhibit the growth of T. cruzi epimastigotes in axenic culture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Alkenes / isolation & purification
  • Alkenes / pharmacology*
  • Animals
  • Lauraceae / chemistry*
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Plant Leaves / chemistry
  • Trypanocidal Agents / chemistry*
  • Trypanocidal Agents / isolation & purification
  • Trypanocidal Agents / pharmacology*
  • Trypanosoma cruzi / drug effects

Substances

  • 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy
  • 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene
  • Alkenes
  • Lignans
  • Trypanocidal Agents