DNA vaccines for biodefence

Helen S Garmory; Stuart D Perkins; Robert J Phillpotts; Richard W Titball

doi:10.1016/j.addr.2005.01.013

DNA vaccines for biodefence

Adv Drug Deliv Rev. 2005 Jun 17;57(9):1343-61. doi: 10.1016/j.addr.2005.01.013. Epub 2005 Apr 13.

Authors

Helen S Garmory¹, Stuart D Perkins, Robert J Phillpotts, Richard W Titball

Affiliation

¹ Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK. hsgarmory@dstl.gov.uk

PMID: 15935877
DOI: 10.1016/j.addr.2005.01.013

Abstract

The advantages associated with DNA vaccines include the speed with which they may be constructed and produced at large-scale, the ability to produce a broad spectrum of immune responses, and the ability for delivery using non-invasive means. In addition, DNA vaccines may be manipulated to express multiple antigens and may be tailored for the induction of appropriate immune responses. These advantages make DNA vaccination a promising approach for the development of vaccines for biodefence. In this review, the potential of DNA vaccines for biodefence is discussed.

Publication types

Review

MeSH terms

Animals
Bacterial Infections / immunology
Bacterial Infections / prevention & control*
Bacterial Vaccines / administration & dosage
Bacterial Vaccines / genetics
Bacterial Vaccines / immunology
Biological Warfare*
Drug Carriers
Drug Delivery Systems / methods*
Humans
Liposomes
Technology, Pharmaceutical / trends*
Vaccines, DNA* / administration & dosage
Vaccines, DNA* / genetics
Vaccines, DNA* / immunology
Viral Vaccines / administration & dosage
Viral Vaccines / genetics
Viral Vaccines / immunology
Virus Diseases / immunology
Virus Diseases / prevention & control*

Substances

Bacterial Vaccines
Drug Carriers
Liposomes
Vaccines, DNA
Viral Vaccines