New pregnane glycosides from Caralluma dalzielii

Steroids. 2005 Aug;70(9):573-85. doi: 10.1016/j.steroids.2005.03.013.

Abstract

Twenty-seven new pregnane glycosides were isolated from the whole plant of Caralluma dalzielii, and their structures elucidated from extensive 2D NMR analysis as well as ESI-MS experiments. All isolated compounds were tested for their antiproliferative activity on J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high potency of cytotoxicities were found in almost all tested compounds, confirming the significant cytotoxic activity of pregnane glycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apocynaceae / chemistry*
  • Cell Line
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry
  • Pregnanes / chemistry*
  • Pregnanes / isolation & purification
  • Pregnanes / pharmacology
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Plant Extracts
  • Pregnanes