Abstract
Twenty-seven new pregnane glycosides were isolated from the whole plant of Caralluma dalzielii, and their structures elucidated from extensive 2D NMR analysis as well as ESI-MS experiments. All isolated compounds were tested for their antiproliferative activity on J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high potency of cytotoxicities were found in almost all tested compounds, confirming the significant cytotoxic activity of pregnane glycosides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Apocynaceae / chemistry*
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Cell Line
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Extracts / chemistry
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Pregnanes / chemistry*
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Pregnanes / isolation & purification
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Pregnanes / pharmacology
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Plant Extracts
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Pregnanes