Abstract
Two new guaiane-type sesquiterpenoids (1 and 2) and one new eudesmane-type sesquiterpenoid (3) were isolated from Saussurea laniceps. The structures of these compounds were established by spectroscopic methods, and the absolute stereochemistry of compounds 1 and 2 was determined by Mosher's method. The immunomodulatory activities of compounds 1-3 were evaluated. Of these, compound 3 showed significant inhibition of the proliferation of murine T and B cells in vitro.
MeSH terms
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Animals
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B-Lymphocytes / drug effects
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Immunologic Factors / chemistry
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Immunologic Factors / isolation & purification*
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Immunologic Factors / pharmacology
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Mice
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Molecular Structure
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Plants, Medicinal / chemistry*
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Saussurea / chemistry*
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Sesquiterpenes, Eudesmane / chemistry
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Sesquiterpenes, Eudesmane / isolation & purification*
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Sesquiterpenes, Eudesmane / pharmacology
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Sesquiterpenes, Guaiane / chemistry
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Sesquiterpenes, Guaiane / isolation & purification*
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Sesquiterpenes, Guaiane / pharmacology
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T-Lymphocytes / drug effects
Substances
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3alpha,7alpha-12-trihydroxyeudesm-4(15)-11(13)-diene
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3alpha,8alpha-dihydroxy-1alphaH,5alphaH,6betaH,7alphaH, 11betaH-guai-4(15),10(14)-dien-6,12-olide 8-O-(2-hydroxy)acrylate
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3alpha,8alpha-dihydroxy-1alphaH,5alphaH,6betaH,7alphaH,11betaH-guai-4(15),10(14)-dien-6,12-olide 8-O-2-hydroxymethylacrylate
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Drugs, Chinese Herbal
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Immunologic Factors
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Sesquiterpenes, Eudesmane
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Sesquiterpenes, Guaiane