Cytotoxicity, antitumoral and antimycobacterial activity of tetrazole and oxadiazole derivatives

Pharmazie. 2005 May;60(5):396-7.

Abstract

In this study, the antimycobacterial activity of mono and di-substituted tetrazole and oxadiazole derivatives and their precursors was assayed on Mycobacterium tuberculosis H37Rv, and cytotoxicity was evaluated on J774 macrophages and on tumoral cell lines. Structure Activity Relationship (SAR) analysis was performed using Principal Component Analysis (PCA) to determine the relationship between these compounds and their biological activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Humans
  • Mycobacterium / drug effects*
  • Oxadiazoles / chemical synthesis*
  • Oxadiazoles / pharmacology*
  • Structure-Activity Relationship
  • Tetrazoles / chemical synthesis*
  • Tetrazoles / pharmacology*
  • Tetrazolium Salts
  • Thiazoles

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Oxadiazoles
  • Tetrazoles
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue