Abstract
Biosynthesized tea polyphenols showed antichlamydial activity against Chlamydia trachomatis D/UW-3/Cx and L2/434/Bu using cell culture. The most active compounds were (-)-epigallocatechin gallate and (-)-epicatechin gallate, followed by (-)-epicatechin (EC). (+)-Epicatechin and (-)-epigallocatechin were intermediate. EC was the least toxic. These results warrant evaluation of tea polyphenols as topical antichlamydial agents.
MeSH terms
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Catechin / analogs & derivatives*
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Catechin / biosynthesis
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Catechin / chemistry
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Catechin / pharmacology
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Chlamydia trachomatis / drug effects*
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Chlamydia trachomatis / growth & development
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Flavonoids / biosynthesis*
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Flavonoids / chemistry
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Flavonoids / pharmacology*
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HeLa Cells / microbiology
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Humans
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Microbial Sensitivity Tests / methods
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Phenols / chemistry
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Phenols / pharmacology*
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Polyphenols
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Tea / chemistry*
Substances
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Anti-Bacterial Agents
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Flavonoids
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Phenols
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Polyphenols
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Tea
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Catechin
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epicatechin gallate
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epigallocatechin gallate