Abstract
It is generally believed that only L-amino acids are acceptable in protein synthesis, though some D-amino acids, including D-tyrosine, D-aspartate, and D-tryptophan are known to be bound enzymatically to tRNAs. In this report, we newly show that D-histidine and D-lysine are also able to be the substrates of respective Escherichia coli aminoacyl-tRNA synthetases.
MeSH terms
-
Amino Acyl-tRNA Synthetases / metabolism*
-
Escherichia coli / metabolism*
-
Esterification
-
Histidine / chemistry*
-
Histidine / metabolism
-
Lysine / chemistry*
-
Lysine / metabolism
-
RNA, Bacterial / chemistry*
-
RNA, Bacterial / metabolism
-
RNA, Transfer / chemistry*
-
RNA, Transfer / metabolism
-
Stereoisomerism
Substances
-
RNA, Bacterial
-
Histidine
-
RNA, Transfer
-
Amino Acyl-tRNA Synthetases
-
Lysine