Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum

Farmaco. 2005 Jun-Jul;60(6-7):475-7. doi: 10.1016/j.farmac.2005.04.001.

Abstract

A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten-Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / pharmacology
  • Animals
  • Electric Stimulation
  • Guinea Pigs
  • Histamine / pharmacology
  • Histamine Antagonists / pharmacology
  • Ileum / drug effects*
  • Ileum / physiology
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy / methods
  • Muscle Relaxation / drug effects*
  • Muscle, Smooth / drug effects*
  • Muscle, Smooth / physiology
  • Potassium Chloride / pharmacology
  • Spectrophotometry / methods
  • Structure-Activity Relationship
  • Tryptamines / chemical synthesis
  • Tryptamines / chemistry
  • Tryptamines / pharmacology*

Substances

  • Histamine Antagonists
  • Tryptamines
  • Potassium Chloride
  • Histamine
  • Acetylcholine