Abstract
A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten-Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / pharmacology
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Animals
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Electric Stimulation
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Guinea Pigs
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Histamine / pharmacology
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Histamine Antagonists / pharmacology
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Ileum / drug effects*
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Ileum / physiology
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In Vitro Techniques
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Magnetic Resonance Spectroscopy / methods
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Muscle Relaxation / drug effects*
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Muscle, Smooth / drug effects*
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Muscle, Smooth / physiology
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Potassium Chloride / pharmacology
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Spectrophotometry / methods
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Structure-Activity Relationship
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Tryptamines / chemical synthesis
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Tryptamines / chemistry
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Tryptamines / pharmacology*
Substances
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Histamine Antagonists
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Tryptamines
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Potassium Chloride
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Histamine
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Acetylcholine