Chlamydia pneumoniae infection as a trigger for a Cogan's syndrome

Dragan Lepur; Zoran Vranjican; Josip Himbele; Igor Klinar; Bruno Barsić

doi:10.1016/j.jinf.2005.04.008

Chlamydia pneumoniae infection as a trigger for a Cogan's syndrome

J Infect. 2006 Mar;52(3):223-6. doi: 10.1016/j.jinf.2005.04.008.

Authors

Dragan Lepur¹, Zoran Vranjican, Josip Himbele, Igor Klinar, Bruno Barsić

Affiliation

¹ Department of Neuroinfections and Intensive Care Medicine, University Hospital for Infectious Diseases Dr Fran Mihaljević, Mirogojska 8, 10000 Zagreb, Croatia. lepurix@inet.hr

PMID: 15904966
DOI: 10.1016/j.jinf.2005.04.008

Abstract

Cogan's syndrome is often preceded by upper respiratory tract symptoms. The only reported specific agent possibly involved in pathogenesis of the Cogan's syndrome was Chlamydia pneumoniae. Positive IgA, IgM and IgG antibodies against C. pneumoniae in our patient suggest possibility of Chlamydia's role as a trigger for the vasculitis.

MeSH terms

Adult
Anti-Inflammatory Agents / therapeutic use
Autoimmune Diseases / drug therapy
Autoimmune Diseases / etiology*
Chlamydophila Infections / complications*
Chlamydophila Infections / drug therapy
Chlamydophila pneumoniae / isolation & purification*
Cyclophosphamide / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Male
Methylprednisolone / therapeutic use

Substances

Anti-Inflammatory Agents
Immunosuppressive Agents
Cyclophosphamide
Methylprednisolone