Immune status in patients with destructive pancreatitis (DP) in long persisting disease and after performance of operative intervention was studied. Signs of secondary combined immunodeficiency were revealed, manifested by decrease of absolute quantity of all lymphocytes populations by 20-70% and concentration of immunoglobulins in blood serum by more than 40%. Conventional therapy did not influence indexes of immunogramm while using immunoglobulin for intravenous injection (IGII), besides saturation of blood by antibodies, the complement activities are increasing as well as indexes of the phagocytes functional state. Application of IGII had promoted the decrease of the patients state severity, normalization of clinico-laboratory data, causing the mortality lowering (P < 0.05), decrease of the treatment duration of survived patients (P < 0.05).