AC electrospray biomaterials synthesis

Biomaterials. 2005 Nov;26(31):6122-8. doi: 10.1016/j.biomaterials.2005.03.033.

Abstract

A rapid, viable and safe fabrication method for biomaterials synthesis is reported using high-frequency AC electrospraying. We demonstrate its potential for polymeric nanoparticle fabrication, drug encapsulation in mono-dispersed micron-sized biodegradable polymer shells and the synthesis of 1microm biodegradable fibers with adjustable pore sizes as bioscaffolds for tissue/orthopaedic engineering and wound care therapy. The absence of charge in the ejected drops and fibers facilitates pulmonary drug delivery, polymer encapsulation and minimizes protein/DNA denaturing or compound ionization.

Publication types

  • Evaluation Study

MeSH terms

  • Biocompatible Materials / analysis
  • Biocompatible Materials / chemical synthesis*
  • Crystallization / methods*
  • Drug Carriers / chemical synthesis*
  • Drug Delivery Systems / methods
  • Electrochemistry / methods*
  • Electromagnetic Fields*
  • Ions
  • Nanostructures / analysis
  • Nanostructures / chemistry*
  • Nanotechnology / instrumentation
  • Nanotechnology / methods*
  • Particle Size
  • Polymers / analysis
  • Polymers / chemical synthesis*

Substances

  • Biocompatible Materials
  • Drug Carriers
  • Ions
  • Polymers