Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Clin Infect Dis. 2005 Jun 1;40(11):1684-8. doi: 10.1086/430068. Epub 2005 Apr 29.

Abstract

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Antifungal Agents / therapeutic use*
  • Child
  • Female
  • Fungi / isolation & purification*
  • Fungi / pathogenicity
  • Granulomatous Disease, Chronic / complications*
  • Humans
  • Lung Diseases, Fungal / complications*
  • Lung Diseases, Fungal / drug therapy*
  • Lung Diseases, Fungal / genetics
  • Lung Diseases, Fungal / microbiology
  • Male
  • Salvage Therapy*
  • Triazoles / therapeutic use*

Substances

  • Antifungal Agents
  • Triazoles
  • posaconazole