The use of biochemical markers in prenatal diagnosis of intrauterine growth retardation: insulin-like growth factor I, Leptin, and alpha-fetoprotein

Eur J Obstet Gynecol Reprod Biol. 2005 May 1;120(1):27-32. doi: 10.1016/j.ejogrb.2004.07.028.

Abstract

Objective: To determine the relation between weight deficit at birth and IGF-I, IGFBP-I, Leptin, and AFP levels in amniotic fluid after 14-18 weeks; to assess the diagnostic usefulness of these biochemical markers.

Study design: Longitudinal, prospective study. Amniocentesis was performed in pregnant women after 14-18 weeks of gestation.

Study population: 86 controls, 18 IUGR <10 percentile, and 17 IUGR <5 percentile.

Results: No significant correlation was found between severity of IUGR and IGF-I, IGFBP-I, or Leptin. AFP was inversely correlated with severity of IUGR; results for the IUGR <10 percentile were: S: 65.7%, SP: 56.9%, PPV: 38.3%, NPV: 80.3%, and an overall diagnostic capacity of 65.6%. Results for the IUGR <5 percentile were: S: 76.4%, SP: 54.8%, PPV: 21.6%, NPV: 93.4% were obtained, and an overall capacity of 70.6%.

Conclusions: Elevated values of AFP in amniotic fluid may help early detection of populations at risk of developing IUGR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amniocentesis*
  • Amniotic Fluid / chemistry
  • Biomarkers / analysis*
  • Fetal Growth Retardation / diagnosis*
  • Gestational Age
  • Insulin-Like Growth Factor Binding Protein 1 / analysis
  • Insulin-Like Growth Factor I / analysis*
  • Leptin / analysis*
  • Longitudinal Studies
  • Prospective Studies
  • Sensitivity and Specificity
  • alpha-Fetoproteins / analysis*

Substances

  • Biomarkers
  • Insulin-Like Growth Factor Binding Protein 1
  • Leptin
  • alpha-Fetoproteins
  • Insulin-Like Growth Factor I