Keeping in mind the frequency of preterm deliveries as well as the morbidity and mortality of the newborn population, many ways of bringing about faster maturation of the fetus have been. Today, we can say that after the 24th week of gestation, when the pneumocites time 2 are anatomically formatted, medical treatment of the fetus for maturation not only of the lungs but all the vulnerable organs is available. By stimulating the pneumocites to make surfactant and sphingomyeline and phosphatidilinositol and phosphatidilglycerol, we can reduce respiratory distress syndrome. Moreover, the frequency of intracranial haemorage is lowered. We have performed many studies with all of their positive and negative effects, including: use of corticosteroids, thyroxine, aminophilline, surfactant, inositole and beta adrenergic agonist.