About 80% of patients become disabled after stroke due to cognitive, motor dysfunctions leading to unsatisfactory daily activity and efficiency. The aims of the research were to evaluate the level of biosocial dysfunctions of patients with stroke by functional independence measure (FIM) and to assess the effectiveness of occupational therapy and factors influencing it. The contingent of the examined patients consisted of 100 patients with stroke and rehabilitated in the Department of Neurorehabilitation of Kaunas University of Medicine Hospital. The findings of the research have shown that occupational therapy is effective to all patients. However, there were significant differences in the averages of FIM points (p<0.05) between low, medium and high effectiveness groups. The conclusion has been made that the effectiveness of occupational therapy is influenced by the following factors: the level of injury, the localization of brain damage, dysuria, passage, memory dysfunctions, unilateral neglect (p<0.05).