Annonaceous acetogenins: the hydroxyl groups and THF rings are crucial structural elements for targeting the mitochondria, demonstration with the synthesis of fluorescent squamocin analogues

Chembiochem. 2005 Jun;6(6):979-82. doi: 10.1002/cbic.200400396.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetogenins
  • Annonaceae / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Azo Compounds / chemistry
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Fatty Alcohols / chemistry*
  • Fatty Alcohols / pharmacology
  • Fluorescence
  • Furans / chemical synthesis*
  • Furans / pharmacology
  • Hydroxyl Radical / chemistry
  • Lactones / chemical synthesis*
  • Lactones / chemistry*
  • Lactones / pharmacology
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Spectrometry, Fluorescence

Substances

  • Acetogenins
  • Antineoplastic Agents, Phytogenic
  • Azo Compounds
  • Enzyme Inhibitors
  • Fatty Alcohols
  • Furans
  • Lactones
  • squamocin
  • Hydroxyl Radical