Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

Org Biomol Chem. 2005 May 7;3(9):1612-4. doi: 10.1039/b503402g. Epub 2005 Apr 4.

Abstract

Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O-O bond are presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Animals
  • Antimalarials / chemical synthesis*
  • Antimalarials / chemistry
  • Antimalarials / pharmacology*
  • Peroxides / chemical synthesis*
  • Peroxides / chemistry
  • Peroxides / pharmacology*
  • Plasmodium falciparum / drug effects

Substances

  • Antimalarials
  • Peroxides