Abstract
Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O-O bond are presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Peroxides / chemical synthesis*
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Peroxides / chemistry
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Peroxides / pharmacology*
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Plasmodium falciparum / drug effects