Association mapping and fine mapping with TreeLD

Bioinformatics. 2005 Jul 15;21(14):3168-70. doi: 10.1093/bioinformatics/bti453. Epub 2005 Apr 26.

Abstract

The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled chromosomes at that position. TreeLD provides an easy-to-use interface and can be applied to case-control, TDT trio and quantitative trait data.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms*
  • Chromosome Mapping / methods*
  • Computer Graphics
  • Polymorphism, Single Nucleotide / genetics*
  • Quantitative Trait Loci / genetics*
  • Sequence Analysis, DNA / methods
  • Software*
  • User-Computer Interface*