Genetic imprinting: conflict at the Callipyge locus

Curr Biol. 2005 Apr 26;15(8):R291-4. doi: 10.1016/j.cub.2005.04.003.

Abstract

The imprinted Dlk1-Gtl2 region of the mammalian genome - which in sheep encompasses the Callipyge locus, known for its unusual mode of inheritance - encodes a number of maternally expressed miRNAs. Five of these miRNAs, hosted by the antisense transcript antiPeg11, have now been shown to target degradation of the paternally expressed Peg11 mRNA by an RNAi-mediated mechanism.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Components
  • Genomic Imprinting / genetics*
  • Glycoproteins / genetics*
  • Humans
  • Inheritance Patterns / genetics
  • Mammals / genetics*
  • Mammals / growth & development
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Mutation / genetics
  • Proteins / genetics*
  • RNA Interference*
  • RNA, Long Noncoding
  • RNA, Messenger / metabolism*

Substances

  • Glycoproteins
  • MEG3 non-coding RNA, human
  • MicroRNAs
  • Proteins
  • RNA, Long Noncoding
  • RNA, Messenger