Direct electron transfer between copper-containing proteins and electrodes

Biosens Bioelectron. 2005 Jun 15;20(12):2517-54. doi: 10.1016/j.bios.2004.10.003. Epub 2004 Nov 18.

Abstract

The electrochemistry of some copper-containing proteins and enzymes, viz. azurin, galactose oxidase, tyrosinase (catechol oxidase), and the "blue" multicopper oxidases (ascorbate oxidase, bilirubin oxidase, ceruloplasmin, laccase) is reviewed and discussed in conjunction with their basic biochemical and structural characteristics. It is shown that long-range electron transfer between these enzymes and electrodes can be established, and the mechanistic schemes of the DET processes are proposed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adsorption
  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods*
  • Coated Materials, Biocompatible / chemistry*
  • Copper / chemistry*
  • Electrochemistry / instrumentation*
  • Electrochemistry / methods*
  • Electrodes*
  • Electron Transport
  • Enzymes, Immobilized / chemistry
  • Protein Binding
  • Proteins / chemistry*

Substances

  • Coated Materials, Biocompatible
  • Enzymes, Immobilized
  • Proteins
  • Copper