The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface

Paul V Murphy; Helge Müller-Bunz; Trinidad Velasco-Torrijos

doi:10.1016/j.carres.2005.02.026

The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface

Carbohydr Res. 2005 May 23;340(7):1437-40. doi: 10.1016/j.carres.2005.02.026.

Authors

Paul V Murphy¹, Helge Müller-Bunz, Trinidad Velasco-Torrijos

Affiliation

¹ Centre for Synthesis and Chemical Biology, Department of Chemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. paul.v.murphy@ucd.ie

PMID: 15854619
DOI: 10.1016/j.carres.2005.02.026

Abstract

The crystal structure of an amphiphilic macrocycle [Velasco-Torrijos, T.; Murphy, P. V., Tetrahedron: Asymmetry2005, 16, 261-272] derived from saccharides shows extensive hydrogen-bonding networks, including participation of water, that may have relevance for the modelling of carbohydrate-carbohydrate recognition at cell-cell interfaces. The structure may provide a basis for understanding the binding of the macrocycle to hydrophobic probes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrates / chemistry*
Crystallography, X-Ray
Glycolipids / chemistry*
Macrocyclic Compounds / chemistry
Molecular Structure

Substances

Carbohydrates
Glycolipids
Macrocyclic Compounds